• Brands (417)
  • Health Concerns (85)
2 Sites 1 Cart
Welcome Valued Customer!
We have a local site for you
Save my choice and dont ask me again

SAMe 400mg 30 Enteric Coated Tablets



Item #: 1672
30 Day Supply
Regular Price: £34.70
Our Price £25.70

Save up to £46.32

In Stock

Save an Extra 5% with EZ-Dispatch »
Text Size: A A A

Product Video

SAMe: For your mood, joints and your liver!

Studies suggest SAMe may help with:

• Relieve depression and stress-related blues
• Treat chronic fatigue syndrome (CFS)
• Lessen arthritis-related pain and inflammation
• Control back pain
• Reduce fibromyalgia symptoms
• Treat hepatitis and other liver disorders
• Protect against Alzheimer's and age-related brain disorders

Much of the SAMe being sold does not meet scientifically accepted standards. The SAM-e molecule has two forms, one is the SS isomer (known as the active isomer) and the other is the RS isomer (known as the inactive isomer). All SAME-e contains percentages of both. The accepted levels for potency of SAM-e require a minimum of 70% SS (active) isomer content. BIOVEA’s SAM-e tests at 74% or higher. Most manufacturers use 50% or even less active isomer content. Consumer Labs tested 30 preparations of SAME-e and only 4 had the acceptable "active ion" SAM-e content.

Once tableted, it must be enteric coated to preserve stability. This technology was not readily available until the 1990’s, hence SAMe’s long road to mainstream popularity.

BIOVEA SAM-e is the highest potency, most scientifically advanced and most highly stabilized SAM-e product available today!

What is SAMe?

SAMe (S-Adenosyl-L-Methionine) acts like a vitamin especially for your mood, your joints and your liver. SAMe can help you feel better physically and emotionally naturally, safely, effectively.

SAM-e is a natural substance that is in every living cell and helps make the brain chemicals (called neurotransmitters) that affect your mood. The most remarkable thing about SAM-e is that it can help you in so many different ways. Not only is SAM-e known for helping to boost mood, but it plays a big role in how you move and how you feel. For example, SAM-e helps support your cartilage—the “cushiony” substance that acts as a shock absorber in your joints. SAM-e has even been observed to support the liver in its cleansing function.

SAMe (pronounced "sammy") is short for S-adenosylmethionine, a molecule that the body continually produces to fuel numerous vital body functions. Discovered in 1952, the popularity of SAMe has soared recently with talk of its ability to ease depression as effectively as prescription antidepressants. (Proponents say SAMe also works faster than antidepressants and with virtually no side effects.)

Health Benefits of SAMe:

The body manufactures SAMe from methionine, an amino acid found in protein-rich foods, and adenosine triphosphate (ATP), an energy-producing compound found in all the body's cells. The SAMe molecule then donates a piece of itself (a methyl group) to body tissues and organs, providing a critical link in methylation, a chemical reaction that occurs billions of times a second throughout the body. In giving up a part of itself, SAMe promotes cell growth and repair.

SAMe also contributes to the formation of key compounds in the brain, including the neurotransmitter dopamine and the mood-enhancer serotonin. In addition, it helps to maintain desirable levels of glutathione, a major antioxidant that protects against cell damage from oxygen molecules called free radicals. Taken as a supplement, SAMe compensates for any deficiencies and encourages the body to run efficiently.

Why Take SAMe?

• Relieve depression and stress-related blues: Several studies indicate that SAMe eases mild to moderately severe depression. A sweeping review of dozens of small clinical trials (called a "meta-analysis") testing SAMe for depression concluded that it appears to work as well as the frequently prescribed tricyclic antidepressants (imipramine, amitriptyline, desipramine) in easing depression. Just as importantly, it works faster, often starting to improve mood within a week. This contrasts significantly with standard antidepressants, whose effects can take several weeks to become apparent. In a University of California study of 17 severely depressed adults, 62% of the participants who took SAMe for four weeks (1,600 mg daily) showed significant improvements in symptoms, compared to 50% of those who used desipramine (a conventional antidepressant). Unlike many prescription antidepressants, which often cause unpleasant side effects such as as drowsiness, dry mouth, and constipation, SAMe appears to cause few if any side effects.

• Treat chronic fatigue syndrome (CFS): Like conventional antidepressants used to treat chronic fatigue, SAMe appears to benefit CFS sufferers by countering depression. It alters the brain's response to pain and improves the quality of badly needed sleep. As a result, both chronic fatigue syndrome and a condition with which it's commonly confused--chronic fatigue syndrome-fibromylagia (CFS-FM)--are likely to respond to SAMe. CFS-FM, which is actually more common than CFS, appears to be a physical response to chronic stress and depression.

• Lessen arthritis-related pain and inflammation: The eventual breakdown of SAMe in the body yields substances that help to keep the gel-like cartilage that cushions joints intact. In the common degenerative joint disease osteoarthritis, cartilage wears down over time. Studies in thousands of osteoarthritis sufferers have demonstrated that SAMe can be as effective at increasing joint mobility and reducing swelling and pain as such NSAIDs (nonsteroidal anti-inflammatories) as ibuprofen and aspirin. Moreover, SAMe doesn't pose the risk of stomach bleeding or kidney damage that are serious risks with NSAIDs. It also doesn't wear down joints, damage cartilage, or block the pain signals that could signal a worsening condition. Although it's not exactly clear how SAMe works for arthritis, very preliminary but intriguing animal studies actually point to a role in repairing cartilage and lubricating joints, properties that may well extend to humans. Clearly more research is needed.

• Control back pain: SAMe may improve back pain when taken for several weeks, a function of its ability to reduce swelling and pain. The theory is that SAMe takes part in the repair and restoration of spinal discs, cartilage, and the articulating surfaces of joints. Obviously, this takes time. So if you're using SAMe for back pain, don't expect the immediate symptom relief that you get with NSAIDs such as Motrin or COX-2 inhibitors such as Vioxx and Celebrex.

• Reduce fibromyalgia symptoms: SAMe may minimize certain complications of this often debilitating disorder, such as muscle pain, depression, and fatigue. The 44 fibromylagia sufferers in a Danish study who took 800 mg of SAMe daily for six weeks reported some relief from morning stiffness and muscle aches. They also noted an improvement in mood. The results from other studies have been mixed, however. For example, a 1997 study to test the effectiveness of intraveneously administered SAMe for fibromylagia failed to show significant benefits. However, given that no single therapy for fibromyalgia is uniformly satisfactory, a trial of SAMe for this often puzzling condition is certainly reasonable.

• Treat hepatitis and other liver disorders: By producing the extremely powerful antioxidant glutathion, which enhances the liver's ability to clear out toxins, SAMe promotes efficient liver function. Research indicates that SAMe may benefit liver function impaired by alcohol-induced cirrhosis, drug toxicity, hepatitis, and cholestasis.

• Protect against Alzheimer's and age-related brain disorders: Preliminary research indicates that SAMe levels are very low in individuals suffering from Alzheimer's disease. In one study of 40 elderly individuals with problems related to alertness and cognition, improvements in such areas as memory, mood, and ability to carry out everyday activities of life occured upon administration of a regimen of oral, intravenous, and intramuscular SAMe. Additional research is now underway to determine what role supplemental SAMe might play in antioxidant production and in disorders of the ageing brain.

Special tips:

To avoid a toxic buildup of homocysteine molecules (which are formed when SAMe breaks down) be sure to take a high-quality vitamin B complex supplement along with SAMe. These vitamins disarm homocysteine, which in high concentrations poses the risk of various health problems including heart attack and stroke. A standard recommendation is to take 100 mg of a B complex once a day, regardless of the SAMe dose.

If you're particularly sensitive to medications, start out with half the recommended daily dosage and work up to the full amount after a week.

For depression, arthritis, fibromylagia and liver disorders:

Take 400 mg of SAMe twice a day. If symptoms fail to improve after three weeks, try increasing your dose to 400 mg three times a day. On the other hand, if symptoms lessen with 400 mg twice a day, you can try to lower the dose to 200 mg twice a day.

Guidelines for Use:

SAMe is best absorbed on an empty stomach, so try to take it about one hour before or two hours after meals. If nausea or heartburn develop, take it with plenty of water.

To prevent insomnia, don't take SAMe late in the day. Most people report a mild energy boost with the supplement.

SAMe can safely be combined with other natural antidepressants such as St. John's wort, as well as conventional antidepressants.

General Interaction:

Don't take SAMe with MAO inhibitor antidepressants.

Clinically proven to help with mood support, joint comfort and liver health.

SAM-e is involved in over 40 biochemical reactions in the body. SAM-e is involved in methylation in the body, which is critical in the manufacturing of many body components, such as brain neurotransmitters like serotonin and dopamine. SAM-e helps regulate these neurotransmitters, that affect our mood. SAM-e is also required for sulfur-containing compounds, such as glutathione, which is a powerful antioxidant in the body that helps fight off substances that damage our cells, particularly in the liver. SAM-e is involved in maintaining and manufacturing cartilage components. Because of the different reactions SAM-e is involved, its benefits vary from joint and liver health, to mood enhancement. SAM-e is recommended to be part of a daily regimen for Mood/Emotional Well-Being, Bone/Joint Health.

Text Size: A A A

Serving Size: One (1) Enteric Coated Tablet
Servings Per Container: 30

Amount Per Serving:
• S-Adenosyl-Methionine (SAM-e) 400mg
(as S-Adenosyl-Methionine Disulfate Tosylate)

Other Ingredients: Cellulose, Cellulose Gum, Methacrylate Polymer, Magnesium Stearate, Stearic Acid, Silica, Citric Acid, Ascorbic Acid, Triethyl Citrate, Coloured with Riboflavin and Titanium Dioxide.

Contains No:  Milk, Egg, Fish, Crustacean Shellfish, Tree Nuts, Wheat, Peanuts, Soybeans, Yeast, Corn, Glutens, Artificial Flavours, Added Sugar, Starch or Preservatives.

Vegetarian and Gluten Free

Text Size: A A A

Take 1 tablet, one time daily, with a meal.

Warning: Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision. If you are pregnant or lactating, consult a health care professional before using this product. KEEP OUT OF REACH OF CHILDREN. Store in a cool, dry place. Do not use this product if the safety seal on the bottle is broken. Do Not Eat Freshness Packet.

4.3 out of 5 stars
5 stars
4 stars
3 stars
2 stars
1 star
Most Helpful Customer Review(s)
by on 29 January 2016
Overall the product is of good quality and I take one in the morning on an empty stomach.
However there is a discrepancy between the packing intructions and the website information. On the package it says take SAMe with food; on the website it says take SAMe on an empty stomach.
Was this review helpful to you?
Better than St Johns Wort
by on 21 April 2016
Seems to work for me
Was this review helpful to you?
I think it's helping
by on 13 March 2016
I have been taking sam-e for just under a month for depression. Wether as a supplement or placebo it seems to be helping.
Was this review helpful to you?
good results, confusing directions
by on 10 March 2016
my first order of SAMe came in a packet - take one tablet with a meal. Noticable improvement in mood. My second order of SAMe has come in a bottle - take one tablet on an empty stomach, refrigerate after opening bottle. There is also a difference in the "other ingredients". Can't find anywhere on the website to contact Biovea.
Was this review helpful to you?
Good supplement
by on 04 March 2016
Good supplement. Felt better a few days after starting it and have had no side effects at all. Prompt delivery too. Will be reordering.
Was this review helpful to you?
Best Quality
by on 27 February 2016
I've been using this brand for several years. Helps greatly with mood regulation - especially in the winter months. Also works a treat for liver issues and alleviates joint pains. A few times I've bought cheaper though still highly reputable brands and found them not as good. I also like this brand as it's free of Folic Acid. Most brands have added Folic Acid. I'd recommend it wholeheartedly for mood, liver and joints.
Was this review helpful to you?
Positive Results
by on 07 February 2016
I have noticed that this Same has a positive effect on more than is advertised . It also helps my arthritis . I was surprised that when I stopped taking them, my pain returned. Give it a couple of days ay 800 mg before it kicks in.
Im sold that this works !
Was this review helpful to you?
Great Product
by on 05 February 2016
These were recommended to my husband a while ago and since he has started taking them for quite bad mood swings, he has felt a great improvement.
We have since recommended these to many friends.
Was this review helpful to you?
Very successful product
by on 29 January 2016
We use this product as part of the profelactic treatment for our son who has Lesch Nyhan Disease - a rare genetic metabolic disease. He started taking this over 10 years ago following reading a clinical report from Australia which highlighted its effectiveness for mood enhancement. It has made a significant difference to his life. My only disappointment has been , on occasions, lack of supply - had to go to a different supplier. In all other respects Biovea has been an excellent supplier - efficient, responsive, easy to use website, punctual delivery.
Was this review helpful to you?
Mood enhancer or pain killer?
by on 27 January 2016
SAMe comes with some well recorded evidence of helping with the symptoms of osteoarthritis, albeit as a side effect of its known mood enhancement action. I don't know which is working in my case, but I do feel better for taking them.
Was this review helpful to you?
Text Size: A A A
Premium Quality Guaranteed Since 2001
BIOVEA is committed to product quality through every step of the manufacturing process: formula development, raw ingredient selection, product testing, controlled storage and transport. Because we feel so strongly about the quality, potency and purity of our products, we 100% guarantee your satisfaction with every purchase at BIOVEA.

BIOVEA branded products go through the stringent processes below to ensure the quality of our products. Our Product Quality Team works closely with other manufacturers to ensure that all of the brands and products available on biovea.com share the same high-level dedication to quality.

Research - BIOVEA dedicates countless resources to the research and development of new products to stay at the forefront of the vitamin and supplement industry. Read More »The benefits of a product are researched extensively before raw ingredients are selected and formulation begins. As new ingredients emerge and new health benefits are discovered, BIOVEA works closely with researchers, manufacturers and suppliers to make sure we always have the latest products available to our customers. Read Less «

Purity - BIOVEA uses ingredients with superior purity, efficacy and bioavailability, ensuring the quality and benefits of the final product. Read More »We work closely with our manufacturers and suppliers to source the highest purity raw ingredients from all over the world. BIOVEA works with a variety of suppliers to guarantee the ability to identify and select the most potent and pure active ingredients for each nutritional product. Read Less «

Manufacturing - Our products are manufactured according to Good Manufacturing processes (GMP) in NSF® certified facilities. Read More »All BIOVEA nutritional products are manufactured exceeding GMP in NSF certified facilities that are carefully monitored and regularly inspected to ensure these high standards are constantly upheld. Read Less «

Testing - Over 25 different standards must be met for each product - ensuring purity and potency and that they are free of any bacterial agents. Read More »Any ingredient that does not meet testing standards is discarded and not used in production. In addition, products are tested for microbial agents, pesticides and other volatile materials as well as screened for harmful agents that can decrease the efficacy of the product and reduce shelf life during the production process. All finished products are tested before packaging to verify that purity, quality and potency have been maintained to specified levels before the products are cleared for distribution. Read Less «

Guarantee - Our 100% Satisfaction Guarantee ensures that you can shop with confidence every time you order with us. Read More »BIOVEA guarantees the quality and labeled potency of our products. Certificates of Analysis for all BIOVEA branded products are available upon request. If for any reason you are dissatisfied with your product, you may return it within 30 days for a store credit, exchange or a full refund. Read Less «


Supplier Qualification Raw Material Specification Packaging Material Specification


Incoming Lot Control Incoming Inspection Hygienic Sampling Laboratory Analysis


Microbial Screening Mineral and Heavy Metals Yeast, Mold and Pesticides


Consistency Moisture Analysis Potency Verification Friability and Hardness


Internal Audit System Metal Detection / X Ray Shelf Life Verification QA Inspection
Frequently Bought Together

Buy this item with 5-HTP (Time Release) 100mg 180 Tablets VALUE PACK

Regular Price Together: £83.20

Our Price Together: £61.60

Buy Items Together ›